Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells
Identifieur interne : 000514 ( Main/Exploration ); précédent : 000513; suivant : 000515Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells
Auteurs : Linlin Chang [République populaire de Chine] ; Sheng Jia [République populaire de Chine] ; Yingying Fu [République populaire de Chine] ; Tianyi Zhou [République populaire de Chine] ; Ji Cao [République populaire de Chine] ; Qiaojun He [République populaire de Chine] ; Bo Yang [République populaire de Chine] ; Xian Li [République populaire de Chine] ; Chongde Sun [République populaire de Chine] ; Dan Su [République populaire de Chine] ; Hong Zhu [République populaire de Chine] ; Kunsong Chen [République populaire de Chine]Source :
- Chinese Medicine [ 1749-8546 ] ; 2015.
Abstract
Ougan (
Ougan fruits were harvested. Flavedo tissues were separated and made into freeze-dried powder. Then OFE were extracted from the powder. The components of OFE were identified by the high performance liquid chromatography system with a detection wavelength of 280 nm for flavanones and 330 nm for polymethoxylated flavones. Cell viability was assessed by Sulforhodamine B assay. The effects on cancer cell migration and motility were evaluated by wound-healing and transwell assays. The mechanisms of action were investigated by examining the modulation by OFE on EMT-related signaling pathways at the concentrations of 4 μg/mL and 20 μg/mL, using qRT-PCR and western blot analyses.
Non-cytotoxic concentrations of OFE significantly suppressed the cellular migration (4 μg/mL,
The anti-metastatic ability of OFE inhibited EMT by interfering with the canonical TGF-β1-SMAD-Snail/Slug axis.
Url:
DOI: 10.1186/s13020-015-0042-0
PubMed: 26131016
PubMed Central: 4486131
Affiliations:
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Zhejiang</orgName></affiliation></author><author><name sortKey="Jia, Sheng" sort="Jia, Sheng" uniqKey="Jia S" first="Sheng" last="Jia">Sheng Jia</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Fu, Yingying" sort="Fu, Yingying" uniqKey="Fu Y" first="Yingying" last="Fu">Yingying Fu</name><affiliation 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Zhejiang</orgName></affiliation></author><author><name sortKey="He, Qiaojun" sort="He, Qiaojun" uniqKey="He Q" first="Qiaojun" last="He">Qiaojun He</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Li, Xian" sort="Li, Xian" uniqKey="Li X" first="Xian" last="Li">Xian Li</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Sun, Chongde" sort="Sun, Chongde" uniqKey="Sun C" first="Chongde" last="Sun">Chongde Sun</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Su, Dan" sort="Su, Dan" uniqKey="Su D" first="Dan" last="Su">Dan Su</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Zhejiang Cancer Hospital, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Cancer Hospital, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhu, Hong" sort="Zhu, Hong" uniqKey="Zhu H" first="Hong" last="Zhu">Hong Zhu</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Chen, Kunsong" sort="Chen, Kunsong" uniqKey="Chen K" first="Kunsong" last="Chen">Kunsong Chen</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement 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xml:lang="en" level="a" type="main">Ougan (<italic>Citrus reticulata</italic> cv. <italic>Suavissima</italic>) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells</title><author><name sortKey="Chang, Linlin" sort="Chang, Linlin" uniqKey="Chang L" first="Linlin" last="Chang">Linlin Chang</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Jia, Sheng" sort="Jia, Sheng" uniqKey="Jia S" first="Sheng" last="Jia">Sheng Jia</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Fu, Yingying" sort="Fu, Yingying" uniqKey="Fu Y" first="Yingying" last="Fu">Yingying Fu</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Zhou, Tianyi" sort="Zhou, Tianyi" uniqKey="Zhou T" first="Tianyi" last="Zhou">Tianyi Zhou</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Cao, Ji" sort="Cao, Ji" uniqKey="Cao J" first="Ji" last="Cao">Ji Cao</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="He, Qiaojun" sort="He, Qiaojun" uniqKey="He Q" first="Qiaojun" last="He">Qiaojun He</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Li, Xian" sort="Li, Xian" uniqKey="Li X" first="Xian" last="Li">Xian Li</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Sun, Chongde" sort="Sun, Chongde" uniqKey="Sun C" first="Chongde" last="Sun">Chongde Sun</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Su, Dan" sort="Su, Dan" uniqKey="Su D" first="Dan" last="Su">Dan Su</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Zhejiang Cancer Hospital, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Cancer Hospital, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhu, Hong" sort="Zhu, Hong" uniqKey="Zhu H" first="Hong" last="Zhu">Hong Zhu</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author><author><name sortKey="Chen, Kunsong" sort="Chen, Kunsong" uniqKey="Chen K" first="Kunsong" last="Chen">Kunsong Chen</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author></analytic><series><title level="j">Chinese Medicine</title><idno type="eISSN">1749-8546</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Ougan (<italic>Citrus reticulata</italic> cv. <italic>Suavissima</italic>) flavedo extract (OFE) exhibited potential anti-tumor effects with unclear underlying mechanisms. This study aims to evaluate the potential anti-metastatic activities of OFE on human ovarian cancer cells, and investigate its inhibitory effect on epithelial-to-mesenchymal transition (EMT).</p></sec><sec><title>Methods</title><p>Ougan fruits were harvested. Flavedo tissues were separated and made into freeze-dried powder. Then OFE were extracted from the powder. The components of OFE were identified by the high performance liquid chromatography system with a detection wavelength of 280 nm for flavanones and 330 nm for polymethoxylated flavones. Cell viability was assessed by Sulforhodamine B assay. The effects on cancer cell migration and motility were evaluated by wound-healing and transwell assays. The mechanisms of action were investigated by examining the modulation by OFE on EMT-related signaling pathways at the concentrations of 4 μg/mL and 20 μg/mL, using qRT-PCR and western blot analyses.</p></sec><sec><title>Results</title><p>Non-cytotoxic concentrations of OFE significantly suppressed the cellular migration (4 μg/mL, <italic>P</italic> = 0.005 vs. control group; 20 μg/mL, <italic>P</italic> = 0.003 vs. control group) and motility (4 μg/mL, <italic>P</italic> < 0.001 vs. control group; 20 μg/mL, <italic>P</italic> < 0.001 vs. control group) of SKOV3 cells, and inhibited transforming growth factor-β1 (TGF-β1)-induced E-cadherin loss (4 μg/mL, <italic>P</italic> = 0.002 vs. control group; 20 μg/mL, <italic>P</italic> = 0.001 vs. control group) and mesenchymal marker upregulation, e.g., N-cadherin (4 μg/mL, <italic>P</italic> = 0.027 vs. control group; 20 μg/mL, <italic>P</italic> = 0.013 vs. control group), vimentin (4 μg/mL, <italic>P</italic> = 0.036 vs. control group; 20 μg/mL, <italic>P</italic> = 0.015 vs. control group) and fibronectin (4 μg/mL, <italic>P</italic> < 0.001 vs. control group; 20 μg/mL, <italic>P</italic> < 0.001 vs. control group).</p></sec><sec><title>Conclusions</title><p>The anti-metastatic ability of OFE inhibited EMT by interfering with the canonical TGF-β1-SMAD-Snail/Slug axis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Siegel, R" uniqKey="Siegel R">R Siegel</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author><author><name sortKey="Hao, Y" uniqKey="Hao Y">Y Hao</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Thun, Mj" uniqKey="Thun M">MJ Thun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiery, Jp" uniqKey="Thiery J">JP 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Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Chang, Linlin" sort="Chang, Linlin" uniqKey="Chang L" first="Linlin" last="Chang">Linlin Chang</name></region><name sortKey="Cao, Ji" sort="Cao, Ji" uniqKey="Cao J" first="Ji" last="Cao">Ji Cao</name><name sortKey="Chen, Kunsong" sort="Chen, Kunsong" uniqKey="Chen K" first="Kunsong" last="Chen">Kunsong Chen</name><name sortKey="Fu, Yingying" sort="Fu, Yingying" uniqKey="Fu Y" first="Yingying" last="Fu">Yingying Fu</name><name sortKey="He, Qiaojun" sort="He, Qiaojun" uniqKey="He Q" first="Qiaojun" last="He">Qiaojun He</name><name sortKey="Jia, Sheng" sort="Jia, Sheng" uniqKey="Jia S" first="Sheng" last="Jia">Sheng Jia</name><name sortKey="Li, Xian" sort="Li, Xian" uniqKey="Li X" first="Xian" last="Li">Xian Li</name><name sortKey="Su, Dan" sort="Su, Dan" uniqKey="Su D" first="Dan" last="Su">Dan Su</name><name sortKey="Sun, Chongde" sort="Sun, Chongde" uniqKey="Sun C" first="Chongde" last="Sun">Chongde Sun</name><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name><name sortKey="Zhou, Tianyi" sort="Zhou, Tianyi" uniqKey="Zhou T" first="Tianyi" last="Zhou">Tianyi Zhou</name><name sortKey="Zhu, Hong" sort="Zhu, Hong" uniqKey="Zhu H" first="Hong" last="Zhu">Hong Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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